No doubt aging is inevitable and scary, but what if science could help us “age better”? Here comes NAD+ (Nicotinamide Adenine Dinucleotide), the silent molecule working behind the scenes in nearly every cell of your body. Often dubbed the “cellular spark plug,” this vital coenzyme plays a pivotal role in numerous biological functions, including cellular energy metabolism, DNA repair, mitochondrial function, and gene regulation. It has emerged as a key player in the anti-aging world, and researchers believe it may hold the secret to healthier, longer lives. Today, more people are turning to NAD+ anti-aging cream as part of their rejuvenation routines.
This blog delves into the importance of NAD+ in our body and aging and how it can help in aging better.
What is NAD+?
NAD+ is a coenzyme found in every living cell. It exists in two forms: NAD+ (oxidized) and NADH (reduced). It plays a critical role in energy production in cells, DNA repair, and activating longevity-related enzymes called sirtuins. Many wellness experts now recommend NAD infusion therapy for their powerful anti-aging and energy-boosting effects.
As we age, our NAD+ levels in our body naturally decline. By the time we hit 50, we may have half as much NAD+ as we did in our 20s. This decline is due to several internal and external factors such as aging, chronic inflammation, chronic stress, environmental toxins and lifestyle choices (e.g., poor diet, lack of exercise). The decline of natural NAD+ has been linked to aging-related issues such as:
- Fatigue
- Cognitive decline
- DNA damage
- Metabolic issues
- Wrinkles, dull and aging skin
- Weakened immune response
Beyond just powering our cells, NAD+ also fuels special proteins like sirtuins, PARPs, and CD38, all of which act like your body’s repair crew, calming inflammation, repairing damaged DNA, and keeping your cells in balance.
The Science of Anti-Aging: NAD+ and its companions
NAD+ and Sirtuins
Sirtuins are a family of proteins dependent on NAD that regulate numerous cellular processes like DNA stability and repair, cellular metabolism and inflammation and Circadian rhythms Among them, SIRT1 and SIRT6 are most heavily involved in aging-related functions.
- SIRT1 regulates inflammation, mitochondrial biogenesis, and stress resistance.
- SIRT6 is known for its role in DNA repair, genomic stability, and telomere maintenance.
Recent studies highlight how activating SIRT6 via NAD+ pathways could offer therapeutic potential against neurodegeneration and metabolic diseases.
NAD+ Precursors: NMN and NR
NAD+ can’t be taken directly in oral form (it’s too large to cross cell membranes easily), researchers have developed precursor molecules like NMN (Nicotinamide Mononucleotide) and NR (Nicotinamide Riboside) that convert into NAD+ inside cells. If you’re looking for the best NAD+ supplement, these two are your go-tos.
Nicotinamide Mononucleotide (NMN):
- Quickly converted to NAD+ in cells
- Enhances insulin sensitivity, vascular function, and muscle strength
- Increases mitochondrial density
Nicotinamide Riboside (NR):
- Found in trace amounts in milk and some vegetables
- Improves lipid metabolism and cognitive performance
A study showed that daily NMN supplementation improved endurance, improved markers of metabolic health, insulin sensitivity and mitochondrial efficiency in aging models.
NAD+ and Skin Aging
The skin, being the body’s largest and most visible organ, reveals the impact of NAD+ depletion through dullness, wrinkling, loss of elasticity and slower wound healing. This has sparked rising interest in NAD+ face cream, NAD+ prescription skincare, and medical-grade NAD+ cream.
Boosting your NAD+ levels helps wake up the skin’s repair cells, ramps up collagen production, and keeps your skin looking firm, smooth, and youthful.
NAD+ Benefits: Beyond Anti-Aging
Supplementing NAD+ precursors can lead to a cascade of health benefits:
- Brain: Better focus, memory, and neuroplasticity
- Muscles: Improved strength, stamina, and recovery
- Cardiovascular: Healthier blood flow, reduced arterial stiffness
- Cellular Health: Slower aging, better DNA repair
- Skin: Radiance, elasticity, and reduced wrinkles
Can NAD+ Reverse Aging? What the Science Says
While “reversing” aging may still be aspirational, current research strongly supports that boosting NAD+ can delay and even improve age-related decline.
A pivotal study in mice demonstrated that NAD+ supplementation could restore mitochondrial function, enhance muscle performance, and extend lifespan. Newer research also suggests synergistic effects when NAD+ is combined with sirtuin activators and senolytics.
Conclusion: Is NAD+ the Future of Youthful Living?
While long-term human studies are still needed, early results are promising.
If you’re exploring NAD+ supplementation, always consult a healthcare provider and choose products that offer scientific transparency and proven absorption.
At MyProfusions, we’re passionate about bringing science-backed, premium NAD+ solutions to your wellness routine, so you can feel energized, resilient, and radiant at every age.
References
- Imai, S., & Guarente, L. (2014). NAD+ and sirtuins in aging and disease. Trends in cell biology, 24(8), 464–471. https://doi.org/10.1016/j.tcb.2014.04.002
- Fang, E. F., Lautrup, S., Hou, Y., Demarest, T. G., Croteau, D. L., Mattson, M. P., & Bohr, V. A. (2017). NAD+ in Aging: Molecular Mechanisms and Translational Implications. Trends in molecular medicine, 23(10), 899–916. https://doi.org/10.1016/j.molmed.2017.08.001
- Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., Yoshino, J., & Imai, S. I. (2016). Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice. Cell metabolism, 24(6), 795–806. https://doi.org/10.1016/j.cmet.2016.09.013
- Jiang, Z., Luo, L., Qin, Y., Huang, Y., Yan, S. (2025). Nicotinamide Adenine Dinucleotide and Aging. In: Qin, ZH. (eds) Biology of Nicotinamide Coenzymes. Springer, Singapore. https://doi.org/10.1007/978-981-97-9877-3_28
- Grinin, L., Grinin, A., Korotayev, A. (2024). Anti-aging as a Key Challenge for the Medicine of the Future. In: Cybernetic Revolution and Global Aging. World-Systems Evolution and Global Futures. Springer, Cham. https://doi.org/10.1007/978-3-031-56764-3_11
- B, V. (2024, January 31). Antiaging supplements: How nad, NMN, and SIRT 6 Activators Battle Aging. Healthy Living Journey. https://healthyliving-journey.com/antiaging-supplements-nad-nmn-and-sirt-6
- Zhang, Y., Li, Q., Niu, Y., Wei, K., Wang, X., Niu, B., & Zhang, L. (2023). Research progress on aging mechanism and drugs and the role of stem cells in anti-aging process. Experimental Gerontology, 179, 112248. https://doi.org/10.1016/j.exger.2023.112248
