Personalized Acne & Skincare Treatment | Profusions Wellness

Personalized Acne & Skincare Treatment

Save with the larger plans
Tretinoin 0.05% Cream (retinoid — gold standard for acne & anti-aging)
15g Monthly Plan $189/mo
45g 3-Month Plan $83/mo
Spironolactone 25mg (oral — primarily prescribed to women for hormonal acne)
30 pills $119
60 pills $149
90 pills $199
Spironolactone 50mg (higher-dose — primarily prescribed to women)
30 pills $119
60 pills $149
90 pills $199
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✦ Provider-reviewed. Pharmacy-dispensed.

*Pricing Disclosure — Pricing reflects a 3-month program when paid in full or through available financing options. Final cost may vary based on the medication and dosing plan determined during the clinical review process.

**Pregnancy Warning — Tretinoin is contraindicated in pregnancy. Spironolactone may cause feminizing effects in male patients and is contraindicated in those with hyperkalemia, severe kidney disease, or Addison’s disease. All medications require provider review for eligibility.

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Acne treatment medications — Tretinoin and Spironolactone compounded online
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Pharmaceutical-grade compounding

Prepared by licensed U.S. pharmacies, third-party tested for purity.

Free discreet shipping

Delivered to your door, fast and private.

No membership fees

Pay only for your treatment plan — no hidden charges.

Provider-led plans & ongoing support

Licensed providers in your state, available for check-ins.

Tretinoin (a vitamin-A derivative) is the gold-standard topical retinoid for acne, fine lines, and skin texture — it works by accelerating skin cell turnover and unclogging pores. Spironolactone is an oral aldosterone-antagonist that blocks the androgen receptors driving sebum overproduction — most commonly prescribed to women experiencing hormonal acne (often jawline / lower-face acne that persists into adulthood).

Care that’s built around you — not a one-size-fits-all routine. Your journey begins with a detailed review by a licensed provider who evaluates your skin type, hormonal pattern, and goals. From there, the right combination is recommended and your prescription is dispensed by a state-licensed pharmacy.

Personalized care. Provider-reviewed. Pharmacy-dispensed.
Tretinoin is a topical retinoid (a vitamin-A derivative) and the most clinically validated active ingredient in dermatology. It works by accelerating skin cell turnover, unclogging pores, fading post-acne marks, smoothing fine lines, and improving overall skin texture. It’s used for both acne and anti-aging — and is considered the gold-standard topical treatment for both.
Spironolactone is primarily prescribed to women experiencing hormonal acne — typically presenting as deep, painful breakouts along the jawline, chin, and lower face that flare with menstrual cycles. It works by blocking androgen receptors and reducing sebum production. It is generally NOT prescribed to men for cosmetic acne due to its anti-androgen effects (which can cause feminizing side effects). Your provider will review your medical history to determine eligibility.
Tretinoin requires patience — most users experience an initial “purge” phase (4–6 weeks of worse-looking skin as deeper congestion surfaces), followed by clearer skin starting around weeks 8–12, with broader anti-aging results visible at 4–6 months. Spironolactone typically shows acne improvement at 8–12 weeks. Both work best with consistent daily use.

Care, Tailored to You. Insurance not needed.

Every plan is reviewed by a licensed provider and designed around your unique skin profile and goals. Reassurance assured.

Tretinoin & Spironolactone

A topical retinoid for acne and anti-aging, paired (when appropriate) with oral spironolactone for hormonal acne in women.

Tretinoin and Spironolactone — compounded acne treatment medications

Provider Check-Ins

Ongoing access to your licensed provider for dose adjustments and progress reviews — including blood-test interpretation for spironolactone.

Provider Check-Ins

Free expedited shipping

Discreet packaging, fast delivery — your prescription arrives ready to use from day one.

Free Expedited Shipping

Tretinoin and spironolactone are FDA-approved active ingredients. Prescriptions are issued following a review of your health information by a licensed provider. Tretinoin is contraindicated in pregnancy. Spironolactone requires periodic blood work to monitor potassium and kidney function.

Starting is as simple as 1-2-3

From your first form to your first dose — designed to be simple, safe, and supportive every step of the way.

1

Complete your intake form

Share your skin history, current routine, and goals through our secure online form. Takes about 5 minutes — no waiting rooms, no insurance hassle.

2

Receive your treatment

A licensed provider reviews your information and, when appropriate, prescribes the right medication and dose. Your prescription ships free, fast, and discreetly to your door from a state-licensed pharmacy.

3

24/7 medical support

Message your care team anytime — for dose adjustments, side-effect questions, or progress check-ins. We’re with you for the long haul, not just the first order.

Begin your medically-led skincare journey today

  • 1-on-1 guidance from licensed health providers
  • No-cost consultations for treatment optimization
  • Fast & reliable deliveries with 24/7 support
  • Transparent pricing — no hidden fees, ever
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Acne treatment for men — clear-skin lifestyle photo
20%
of men
ADULT acne
AMERICAN ACADEMY OF DERM.
why hormonal acne treatment matters*

What our clients say about us

You are the purpose. Your turn.

Learn more about Acne & Skincare Treatment

No — but they’re related. Retinol is an over-the-counter vitamin-A derivative that the skin must convert into retinoic acid (the active form) over multiple steps. Tretinoin IS retinoic acid — already in active form, so it’s far more potent and works much faster. This is why tretinoin is prescription-only and retinol is not.
No. Profusions offers acne and skincare treatment with flexible, month-to-month options. You may cancel at any time. That said — both tretinoin and spironolactone work through ongoing biological mechanisms, so stopping treatment generally allows acne to return. Your provider will discuss long-term planning during your check-ins.
Possibly. Tretinoin is contraindicated in pregnancy. Spironolactone is contraindicated in patients with hyperkalemia (high potassium), severe kidney disease, Addison’s disease, or those taking certain medications (potassium supplements, ACE inhibitors, ARBs in high doses). Your licensed provider will review your full medical history during intake.
Tretinoin: dryness, peeling, redness, sun sensitivity (especially in the first 4–8 weeks). Most patients build tolerance with consistent use. Spironolactone: increased urination (it’s a mild diuretic), occasional menstrual irregularity, possible breast tenderness, and rarely, elevated potassium. Your provider may order periodic blood work to monitor potassium levels.
Yes. Most patients start at lower strengths and step up based on tolerance and results. Tretinoin can move from 0.025% → 0.05% → 0.1% as the skin acclimates. Spironolactone often starts at 25mg and can move to 50mg, 75mg, or 100mg daily. Ongoing messaging access lets you flag changes between scheduled check-ins.
Compounded medications are prepared by licensed pharmacies to meet specific patient needs when commercially available options may not be suitable. They can be customized in form and dosage as directed by a licensed provider. Tretinoin and spironolactone are also available in standard FDA-approved forms; your provider will recommend the appropriate option.
Apply a pea-sized amount to clean, dry skin (wait 20–30 minutes after washing your face — applying to wet skin increases irritation). Use only at night. Start with 2–3 nights per week and gradually increase to nightly use as your skin tolerates. Less is more — a pea-sized amount is enough for the entire face.
Yes — daily broad-spectrum SPF 30+ is mandatory. Tretinoin makes your skin significantly more sun-sensitive, and UV exposure during use can cause burns and accelerate the aging it’s trying to prevent. Apply sunscreen every morning, reapply every 2 hours during sun exposure, and consider seeking shade or wearing a hat when possible.
A temporary worsening of skin during the first 4–6 weeks of tretinoin use, as deeper congestion is brought to the surface faster. It looks like increased breakouts but is actually a sign the medication is working. The purge typically resolves by week 8, and most users see clearer skin than baseline by week 12. Patience and consistency are key.
Layering can be done with care, but spacing matters. Vitamin C in the morning + tretinoin at night is a common pairing. AHAs (glycolic, lactic acid) and BHAs (salicylic acid) are best used on alternating nights to avoid over-irritation. Your provider can help you build a routine that includes any other actives you’re using.
Once or twice daily, with or without food. Take it with plenty of water. Try to take it at the same time each day. Avoid taking spironolactone right before bed — its mild diuretic effect can cause overnight bathroom trips. Most providers recommend taking it in the morning or early afternoon.
Spironolactone affects how the kidneys handle potassium and sodium, so periodic blood work (basic metabolic panel) checks your potassium and kidney function. Most providers order baseline labs before starting and again at 4–6 weeks, then less frequently. This is routine and inexpensive — your provider will guide you through it.
Generally not for cosmetic acne. Spironolactone has anti-androgen effects that can cause feminizing side effects in men (gynecomastia, decreased libido). Men with hormonal acne are typically prescribed alternatives such as oral isotretinoin, topical actives, or specific oral antibiotics depending on the case. Tretinoin is fully appropriate for men.
Tretinoin: store in a cool, dry place away from direct sunlight (light degrades the active ingredient). Don’t keep it in a steamy bathroom — humidity reduces shelf life. Spironolactone tablets: room temperature, away from moisture, in original labeled bottle. Both should be kept out of reach of children.
For tretinoin: skip the missed application and apply again the next night. Don’t double up — extra tretinoin causes irritation, not faster results. For spironolactone: take it as soon as you remember, unless it’s close to your next dose, in which case skip and resume your normal schedule. Don’t double up.
Yes. Keep medications in their original labeled containers with prescription information. Tretinoin tube fits within standard liquid limits in carry-on luggage. Spironolactone pills can travel anywhere. Use a UV-protective travel pouch for tretinoin if you’ll be exposed to direct sun. Don’t leave medications in hot cars.

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No hidden fees Personalized plans Free shipping
*Price shown reflects the Tretinoin 45g 3-Month plan ($249 / 3 months). Spironolactone is also available in 25mg or 50mg pill packs (one-time purchase). Actual price depends on the medication and clinical review.
Spironolactone for acne — prescription pills

Disclaimer

Only available if prescribed after an online consultation with a healthcare provider. Tretinoin is contraindicated in pregnancy and increases sun sensitivity — daily SPF 30+ is required during use. Spironolactone may cause feminizing effects in male patients and is contraindicated in those with hyperkalemia, severe kidney disease, or Addison’s disease. Periodic blood work may be required for spironolactone use. Plans are offered as a subscription service which can be canceled at any time. Actual product packaging may appear differently than shown. The statements on this page have not been evaluated by the FDA. All therapies are administered in accordance with applicable state and federal laws. Results may vary. *Adult acne prevalence reference: American Academy of Dermatology — approximately 1 in 5 women experience adult acne after age 25.

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